“A shocking wealth of reproductive physiology knowledge.” — Subodh Chauhan, MD
Term Stim™ is a proprietary service for in-depth research on individual poor-egg-quality cases. It is delivered in collaboration with the ordering physician through a research-grade EMR built to analyze patient data in the context of the new physiology of the reproductive cycle, to reveal the underlying reasons for poor egg quality and to develop a protocol to address it. The name – Term Stim™ – derives from a key consequence of that paradigm; however, not all protocols require a “term” approach (i.e., carrying follicular development to term).
In 2020 we corrected an 80-year misconception at the very core of human reproductive physiology explaining why progesterone, not estradiol, is a physiological trigger of ovulation.
The new ovulation paradigm offers a unifying framework for several phenomena that had remained unresolved for decades: the variability and age-related shortening of the menstrual cycle, the consistency of single-egg ovulation, the link between vanishing follicles and post-mature oocytes, the impact of follicular-phase duration on egg quality, and the mechanisms of reproductive aging – even providing a new explanation for key features of PCOS.
It also introduced the concept of term maturation of the egg – the idea that, much like gestation, an oocyte requires a minimum “term” of development to reach full competence. Early clinical evidence, including published case reports, supports this concept.
The new ovulation paradigm has completely reshaped our view of reproductive cycle and identified new entry points to control egg quality.
In medicine, AI is very successful at searching for and applying a template that worked for a similar patient. But in cases of poor egg quality, this approach is rarely fruitful, since each case is unique. Therefore, in Term Stim™, we use AI only to help track relevant variables and identify subtle trends in a patient’s data that might otherwise be overlooked. However, all validation, interpretation, and recommendations remain entirely human – grounded in research, experience, and expertise.
Progesterone is a physiological trigger of ovulatory gonadotropins. Dozortsev D, Pellicer A, Diamond MP.Fertil Steril. 2020 May;113(5):923-924. doi: 10.1016/j.fertnstert.2019.12.024. Epub 2020 Feb 12.PMID: 32059812
Two peas from the same pod: vanishing follicles and postmature oocytes. Dozortsev DI, Diamond MP.Fertil Steril. 2022 Jan;117(1):40-41. doi: 10.1016/j.fertnstert.2021.09.027. Epub 2021 Nov 6.PMID: 34753599
Premature progesterone rise as a trigger of polycystic ovarian syndrome. Dozortsev DI, Pellicer A, Diamond MP.Fertil Steril. 2020 Nov;114(5):943-944. doi: 10.1016/j.fertnstert.2020.07.007. Epub 2020 Oct 6.PMID: 33036794
Term oocyte maturation and term ovarian stimulation: impact on oocyte competence. Dozortsev DI, Pellicer A, Diamond MP.Fertil Steril. 2020 Aug;114(2):221-222. doi: 10.1016/j.fertnstert.2020.04.013. Epub 2020 Jul 1.PMID: 32622662
Oscillations of estradiol and gonadotropins are a missing link to solving the mystery of mono-ovulation in humans. Dozortsev DI, Pellicer A, Diamond MP.Fertil Steril. 2021 Sep;116(3):630-632. doi: 10.1016/j.fertnstert.2021.05.107. Epub 2021 Jul 22.PMID: 34303510
Luteinizing hormone-independent rise of progesterone as the physiological trigger of the ovulatory gonadotropins surge in the human. Dozortsev DI, Diamond MP.Fertil Steril. 2020 Aug;114(2):191-199. doi: 10.1016/j.fertnstert.2020.06.016. PMID: 32741458
Ovulation and birth after administration of progesterone trigger-two case reports. Villar L, Tralik B, Diamond MP, Allon M, Maldonado I, Dozortsev DI.J Assist Reprod Genet. 2023 May;40(5):1037-1044. doi: 10.1007/s10815-023-02750-x. Epub 2023 Feb 20.PMID: 36808579
Term Stimulation – two case reports. Villar L, Diamond MP, Maldonado I, Dozortsev D. Journal of IVF-Worldwide. 2023;1(1-3).
Disclaimer: The information provided is not intended as medical advice. Repronova LLC offers consulting and advisory services in reproductive physiology exclusively to participating physicians, who are fully licensed in their respective jurisdictions and who retain full clinical discretion and control over the diagnosis, care, and treatment of their patients.
