All easy cases are alike, but each difficult one is challenging in its own unique way. Once conventional options are exhausted, the standard of care becomes a scientific challenge. That’s when Repronova steps in to support you with an advanced reproductive physiology knowledge base—to take a deeper look and help develop and execute a genuinely individualized strategy.
Approximately 90% of embryos that fail to develop to the blastocyst stage, and about 85% of chromosomal errors in blastocysts, can be attributed to suboptimal egg quality. The silver lining is that all eggs within a woman’s ovaries are chromosomally normal until the LH surge or an artificial trigger, regardless of co-morbidities or age. The challenge is to preserve their normality. This can be done in the context of IVF/IUI or a natural cycle.
The conventional approach to ovarian stimulation relies on follicle size and estradiol levels to infer egg competence, with success often measured by the number of retrieved oocytes displaying a first polar body. While this method is sufficient for many patients, it falls short in complex cases where egg quality – not just quantity – becomes the critical factor.
Since 2020, the field of IVF has undergone transformative change, driven by groundbreaking research from Dr. Dmitri Dozortsev, Dr. Antonio Pellicer, and Dr. Michael P. Diamond. Their work redefined the foundational principles of ovarian physiology that have shaped reproductive medicine for nearly a century. They demonstrated why follicular size, estradiol levels, and the presence of a polar body are unreliable indicators of egg quality.
This new paradigm offers a higher level of control over oocyte quality, opening the door to solutions for cases once considered untreatable such as repeated poor embryo development, recurrent implantation failure, and early pregnancy loss.
Repronova provides physicians with the tools and expert support to apply this advanced physiology in clinical practice. Our platform enables you to submit complex cases for in-depth analysis and receive a customized strategy designed to optimize your patient’s egg quality and improve outcomes.
Progesterone is a physiological trigger of ovulatory gonadotropins. Dozortsev D, Pellicer A, Diamond MP.Fertil Steril. 2020 May;113(5):923-924. doi: 10.1016/j.fertnstert.2019.12.024. Epub 2020 Feb 12.PMID: 32059812
Two peas from the same pod: vanishing follicles and postmature oocytes. Dozortsev DI, Diamond MP.Fertil Steril. 2022 Jan;117(1):40-41. doi: 10.1016/j.fertnstert.2021.09.027. Epub 2021 Nov 6.PMID: 34753599
Premature progesterone rise as a trigger of polycystic ovarian syndrome. Dozortsev DI, Pellicer A, Diamond MP.Fertil Steril. 2020 Nov;114(5):943-944. doi: 10.1016/j.fertnstert.2020.07.007. Epub 2020 Oct 6.PMID: 33036794
Term oocyte maturation and term ovarian stimulation: impact on oocyte competence. Dozortsev DI, Pellicer A, Diamond MP.Fertil Steril. 2020 Aug;114(2):221-222. doi: 10.1016/j.fertnstert.2020.04.013. Epub 2020 Jul 1.PMID: 32622662
Oscillations of estradiol and gonadotropins are a missing link to solving the mystery of mono-ovulation in humans. Dozortsev DI, Pellicer A, Diamond MP.Fertil Steril. 2021 Sep;116(3):630-632. doi: 10.1016/j.fertnstert.2021.05.107. Epub 2021 Jul 22.PMID: 34303510
Luteinizing hormone-independent rise of progesterone as the physiological trigger of the ovulatory gonadotropins surge in the human. Dozortsev DI, Diamond MP.Fertil Steril. 2020 Aug;114(2):191-199. doi: 10.1016/j.fertnstert.2020.06.016.
PMID: 32741458
Ovulation and birth after administration of progesterone trigger-two case reports. Villar L, Tralik B, Diamond MP, Allon M, Maldonado I, Dozortsev DI.J Assist Reprod Genet. 2023 May;40(5):1037-1044. doi: 10.1007/s10815-023-02750-x. Epub 2023 Feb 20.PMID: 36808579
Term Stimulation – two case reports. Villar L, Diamond MP, Maldonado I, Dozortsev D. Journal of IVF-Worldwide. 2023;1(1-3). doi:10.46989/001c.87674
Our service – Fertility Grand Round™ enables physician a much deeper insight into patient’s data to create truly personalized treatment plan. This plan may include ovarian stimulation protocols designed to improve egg quality in specific patients, which is managed using our proprietary software built around Term Stim™ paradigm. Much information about Term Stim™ is freely available, including the patent-pending algorithm, lectures, presentations, and publications. Many physicians have begun using elements of Term Stim™ in their practice to extend the follicular phase and reduce circulating FSH, while mitigating the risks of premature luteinization. However, true deep customization requires using the Repronova platform.
Incorporating a complex IVF case into the established care flow is challenging because it effectively becomes a research project that does not fit into the existing structure, tying up a disproportionate amount of your practice’s resources.
Repronova fits a complex IVF case into your practice by taking care of collecting and organizing patient’s records for an analysis. At your order we will also coordinate patient’s diagnostic cycle.
Start by contacting us by phone or by submitting a form. You will receive a contract for electronic signature, as well as credentials to log into the Repronova online platform, where you can present and manage your case with our assistance. Once we receive your payment, we will begin researching the case.
